BMI OrganBank's laboratory platform, CaVESWave, drives the provision of Contract Research Services.
We offer customized and industry standard pre-clinical translational research services, supporting ex vivo and in vivo studies related to Immunology and Inflammation, Tissue Engineering, Regenerative Medicine, Organ and Vascularized Composite Allotransplantation, Diabetes, Cardiovascular Disease, Obesity, Neurodegenerative Disorders and Cancer Biology.
Expertise
Leading perfusion research experts performing in vivo and ex vivo research to discover how new drugs are affecting organs.
Technology
Our patented cardio-vascular emulating CaVESWave® system has proven itself to be a versatile ex vivo and pharmacodynamic research platform, empowering vital research.
Specialty Lab Services and BioMarker Assays
The Ex Vivo Alliance (e.v.a) empowered by BMI OrganBankTM offers access to advanced laboratory services to support biomarker discovery and analysis methods such as immune monitoring, genomics, and bioanalysis to accelerate drug, vaccine and therapeutic development.
Our full-service suite of services come with powerful translational informatics and computational biology approaches that maximize information from each sample and study subject. The goal is to allow predictive modeling and biomarker signature development in transplant immunology, organ preservation, and drug discovery.
ExVivo Organ and Tissue Preservation Studies
Our cardiovascular emulating CaVESWave® laboratory platform is allowing clinicians and researchers to advance organ preservation through novel oxygen delivery technologies, perfusates, cellular, drug, and gene therapies evaluated ex vivo and in vivo in pre-clinical animal and human models.
Examples of services provided include:
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Tissue analysis (histopathology, cellular and molecular imaging),
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Cell profiling (flow cytometry and mass cytometry),
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Biomarker analysis (multiplex cytokine assays),
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Pharmacokinetic and pharmacodynamic testing (LC/MS-MS with advanced quadrupole instrumentation),
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Genomic quantitation (nCounter Nanostring ® assay).
e.v.a. services proactively address challenges of sample size and statistical methodology in translational sciences.
e.v.a offers expert biostatisticians and statistical programmers to craft detailed study plans, including precise definitions of endpoints and descriptions of analyses, to address regulatory risks and maximize success from the outset.
Our Team of Experts
Carrie DiMarzio has dedicated her career to creating a better future by using her leadership skills in tandem with her expertise in science and engineering. DiMarzio is the CEO of BioMedInnovations LLC (BMI) and Industrial Hard Carbon LLC (IHC).
At BMI, DiMarzio leads a team of experts in perfusion technology that will advance organ transplantation and novel ex vivo laboratory research – both projects have the potential to save thousands of lives. She guides partnerships of BMI with organizations such as the Wake Forest Institute for Regenerative Medicine (WFIRM), Lawrence Livermore National Laboratory (LLNL), Duke Ex-Vivo Organ Laboratory (DEVOL), Cystic Fibrosis Foundation, and RegenMed Development Organization (ReMDO). Additionally, DiMarzio also serves on the Executive Leadership Council Board of ReMDO. During her time at BMI, DiMarzio has led successful negotiations with the US FDA, gaining FDA EUA status for BMI’s SuppleVent™ device for use during the COVID-19 pandemic. DiMarzio’s current endeavor is guiding OrganBankTM technology – a proprietary organ preservation system – through the FDA clearance project.
As noted, DiMarzio also serves as CEO for IHC, a precision engineering business that serves the bio-medical, aerospace, and automotive sectors, providing microscopically thin and diamond-like hard surface film modifications that vastly improve equipment performance and durability.
DiMarzio has relevant business experience in sales and marketing as well as quality control, can help to guide business owners on the difficult road toward increased efficiency and productivity, and has an in-depth familiarity with human capital development. DiMarzio is known for her attention to detail, her equal commitment to her company, team, and stakeholders, and her remarkable ability to elicit ‘personal bests’ from each member of the high-performing teams under her charge.
When DiMarzio is not making a difference by managing cutting-edge projects at these two innovative companies based in North Carolina, she engages deeply with her local church and community, coaches female sports for the local schools, and is significantly involved in global outreach programs to provide for those in need.
Distinguished Professor and Vice Chair Clinical Affairs and Chief of the Division of Abdominal Transplant at UNC.
2020, US Secretary of Defense awarded the Defense Meritorious Service Medal to Dr. Gerber for exceptionally meritorious service for the Armed Forces.
In 2010 David was appointed by the Secretary of the Department of Health and Human Services (HHS) to the Advisory Committee on Transplantation.
One of America’s foremost expert perfusionists
14 years from research and development of perfusion tech
Co-author of many peer reviewed publications and papers
Leading the BMI lab at Duke Hospital
14 years from research and development of perfusion tech
Co-author of many peer reviewed publications and papers
Leading the BMI lab at Duke Hospital
World leading expert in design and development of advanced and automated perfusion systems
30+ years of engineering experience from US security clearance systems
US veteran who has held security clearance
30+ years of engineering experience from US security clearance systems
US veteran who has held security clearance
30+ years of advanced medical program development and engineering
Worked on multiple groundbreaking medical advancement systems
Worked on multiple groundbreaking medical advancement systems
Our Partners
Duquesne University
School of Pharmacy
Duke University
ExVivo Organ Lab (“DEVOL”)
RegenMed Development Organization (ReMDO)
Atrium Health,
Wake Forest Institute of Regenerative Medicine (“WFIRM”)
Department of Defense
Armed Forces Institute for Regenerative Medicine (AFRIM)
UNC Kidney Center
US National Lab
Department of Energy
Department of Neuroscience, Yale School Of Medicine, Sestan Lab
