BioMedInnovations, LLC – Winston-Salem, NC – August 03, 2022
BioMedInnovations (BMI) reports the publication of a new article in the prestigious journal Nature – “Cellular recovery after prolonged warm ischaemia of the whole body” – from the Sestan Lab of the Neuroscience department of the Yale School of Medicine, which uses a critical BMI technology component as part of their organ and tissue perfusion platform.
Earlier studies by the Sestan lab involved the restoration and maintenance of microcirculation and molecular/cellular functions of an intact pig brain under ex vivo at normal body temperature for up to four hours post-mortem using a platform that emulates the body’s natural rhythms to mimic a physiological environment for organ preservation. In their new Nature study Andrijevic, Vrselja, Lysyy, Zhang, and Colleagues extended the application of this platform from the pig brain to the whole pig body.
After an hour of warm ischemia induced by halting circulation by stopping the heart, a six-hour perfusion preserved tissue integrity, inhibited cell death, and restored crucial molecular and cellular processes in multiple organs. Later analysis at the single-cell scale also found that perfusion of the pig body induced organ- and cell-type-specific molecular and cellular repair processes. In the future, the application of this platform may provide a means to maintain human organs in a viable condition for longer times and increase the supply of much-needed organs for later research or transplantation purposes, thereby solving our current problem of severe organ shortages.
Overall, this exciting study from the Sestan Lab provides robust evidence that an organ and tissue perfusion platform containing a critical BMI technology component can support the function of multiple organs in a large mammal after prolonged whole-body warm ischemia.