Skip to main content

BioMedInnovations, LLC – Winston-Salem, NC – April 18, 2019

BioMedInnovations reports the publication of a scientific article in the prestigious journal Nature. The brains of humans and other mammals display vulnerabilities to interruptions in blood flow and decreases in oxygen levels. This Nature article describes a study undertaken by the Sestan Lab of the Neuroscience department of the Yale School of Medicine that involved the restoration and maintenance of microcirculation and molecular and cellular functions of an intact pig brain under ex vivo normothermic conditions up to four hours post-mortem.

The internationally renowned research team observed the preservation of cytoarchitecture, attenuation of cell death, and the restoration of vascular dilatory and glial inflammatory responses, spontaneous synaptic activity, and active cerebral metabolism in the absence of global electrocorticographic activity.

These findings demonstrate that the isolated, intact large mammalian brain has an underappreciated capacity for restoring microcirculation and molecular and cellular activity after a prolonged post-mortem interval under appropriate conditions.