Perfusion Research Expert Services

The proprietary BMI OrganBank Lab™ system supports world-class contract research that can reduce the need for testing in live animals and provide novel pharmacokinetic and pharmacodynamic insights.

We offer customized and industry-standard preclinical translational research services, supporting ex vivo and in vivo studies related to immunology and inflammation, tissue engineering, regenerative medicine, organ and vascularized composite allotransplantation, diabetes, cardiovascular disease, obesity, neurodegenerative disorders, and cancer. Our solutions

Expertise

Our perfusion research experts perform in vivo and ex vivo research to discover how new drugs affect organs. We have run dozens of studies to support numerous client applications.

Technology

Our patented cardiovascular-emulating-CaVESWave® technology powers our OrganBank system and supports research in a wide range of organs and animals.

Specialty Lab Services and BioMarker Assays 

The Ex Vivo Institute, powered by OrganBank LabTM, offers access to advanced laboratory services to support biomarker discovery and analysis methods (such as immune monitoring, genomics, and bioanalysis) to accelerate drug, vaccine, and therapeutic development.

Our full-service suite of services comes with powerful translational informatics and computational biology approaches that maximize information from each sample and study subject. Our goal is to support predictive modeling and biomarker signature development in transplant immunology, organ preservation, and drug discovery.

ExVivo Organ and Tissue Preservation Studies ​ 

Our cardiovascular-emulating CaVESWave® technology has allowed clinicians and researchers to improve organ preservation through novel oxygen delivery technologies, perfusates, and cellular, drug, and gene therapies evaluated ex vivo and in vivo in pre-clinical animal and human models.

Examples of services provided include:

  • Tissue analysis (histopathology, cellular, and molecular imaging)

  • Cell profiling (flow and mass cytometry)

  • Biomarker analysis (multiplex cytokine assays)

  • Pharmacokinetic and pharmacodynamic testing (LC/MS-MS with advanced quadrupole instrumentation)

  • Genomic quantitation (nCounter Nanostring®assay)

Ex Vivo Institute offers expert biostatisticians and statistical programmers to craft detailed study plans (including precise definitions of endpoints and descriptions of analyses), address regulatory risks, and maximize success from the outset.

Our Team of Experts

Chief Executive Officer

Carrie DiMarzio

Carrie DiMarzio has dedicated her career to creating a better future by using her leadership skills in tandem with her expertise in science and engineering.

Carrie DiMarzio has dedicated her career to creating a better future by using her leadership skills in tandem with her expertise in science and engineering. DiMarzio is the CEO of BMI OrganBank and Industrial Hard Carbon LLC (IHC).

At BMI OrganBank, DiMarzio leads a team of experts in perfusion technology that will advance organ transplantation and novel ex vivo laboratory research – both projects have the potential to save thousands of lives. She guides partnerships of BMI OrganBank with organizations such as the Wake Forest Institute for Regenerative Medicine (WFIRM), Lawrence Livermore National Laboratory (LLNL), Duke Ex-Vivo Organ Laboratory (DEVOL), Cystic Fibrosis Foundation, and RegenMed Development Organization (ReMDO). Additionally, DiMarzio also serves on the Executive Leadership Council Board of ReMDO. During her time at BMI OrganBank, DiMarzio has led successful negotiations with the US FDA, gaining FDA EUA status for BMI OrganBank’s SuppleVent™ device for use during the COVID-19 pandemic. DiMarzio’s current endeavor is guiding OrganBankTM technology – a proprietary organ preservation system – through the FDA clearance project.

As noted, DiMarzio also serves as CEO for IHC, a precision engineering business that serves the bio-medical, aerospace, and automotive sectors, providing microscopically thin and diamond-like hard surface film modifications that vastly improve equipment performance and durability.

DiMarzio has relevant business experience in sales and marketing as well as quality control, can help to guide business owners on the difficult road toward increased efficiency and productivity, and has an in-depth familiarity with human capital development. DiMarzio is known for her attention to detail, her equal commitment to her company, team, and stakeholders, and her remarkable ability to elicit ‘personal bests’ from each member of the high-performing teams under her charge.

When DiMarzio is not making a difference by managing cutting-edge projects at these two innovative companies based in North Carolina, she engages deeply with her local church and community, coaches female sports for the local schools, and is significantly involved in global outreach programs to provide for those in need.

Chief Medical Officer

David Gerber

Distinguished Professor and Vice Chair Clinical Affairs and Chief of the Division of Abdominal Transplant at UNC.

Distinguished Professor and Vice Chair Clinical Affairs and Chief of the Division of Abdominal Transplant at UNC.

2020, US Secretary of Defense awarded the Defense Meritorious Service Medal to Dr. Gerber for exceptionally meritorious service for the Armed Forces.

In 2010 David was appointed by the Secretary of the Department of Health and Human Services (HHS) to the Advisory Committee on Transplantation.

Varun Kopparthy, VP, Product Development, BMI OrganBank
VP Product Development

Varun Kopparthy

12+ years of medical device development experience focusing on ex vivo organ preservation technology and point-of-care diagnostics.

12+ years of medical device development experience focusing on ex vivo organ preservation technology and point-of-care diagnostics.

Passionate about translating innovations in technology to relevant clinical applications. Broad experience in product development, R&D, Tech transfer, and commercialization of medical devices. Entrepreneurial experience, founding biotechnology startups, securing non-dilutive federal funding, and raising pre-seed capital for product development.

Postdoctoral fellowship in Biomedical Engineering from Cornell University and Ph.D. in Biomedical Engineering from Louisiana Tech University.

Head Of Perfusion

Chip Aardema

One of America’s foremost expert perfusionists

One of America’s foremost expert perfusionists
14 years of research and development in perfusion tech
Co-author of many peer-reviewed publications and papers
Leading the BMI OrganBank lab at Duke Hospital

Our Partners

DukeMedicine_logo
Duke University
ExVivo Organ Lab (“DEVOL”)
WFIRM logo
Atrium Health,
Wake Forest Institute of Regenerative Medicine (“WFIRM”)
ReMDO logo
RegenMed Development Organization (ReMDO)
UNC Health logo
UNC Kidney Center
Duquesne_logo
Duquesne University
School of Pharmacy
Department of Defense Armed Forces Institute for Regenerative Medicine logos
Department of Defense
Armed Forces Institute for Regenerative Medicine
BMI OrganBank is a North Carolina Biotechnology Center portfolio company